Qwen on NVIDIA Blackwell

Can I run Qwen3 235B-A22B on an RTX 5080?

Not at Q4_K_M — it needs 135.1 GB against 14.2 GB available. No quantisation of this model fits on one card.

Won't fit

135.1 GB of 14.2 GB · 949%
0141 GB
Weights 132.8 GB
KV cache 1.5 GB
Runtime overhead 0.8 GB
Over the limit 120.9 GB

Short by 120.9 GB. You can run it with 8 of 94 layers on the RTX 5080 and the rest in system RAM, at roughly 3.36 tok/s — usable for batch work, painful for chat. A smaller quantisation or a shorter context is usually the better trade.

Generation3.36tok/s
Prompt processing1062tok/s
Max context0tokens
KV per 1K tokens0GB

Every quantisation of Qwen3 235B-A22B on a RTX 5080

Highlighted row is the highest quality that still fits at 8K context.

QuantisationbpwWeights TotalVerdictMax ctxtok/s
FP16 / BF16 16.00 437.9 GB 440.2 GB Won't fit 1.02
INT8 / W8A8 8.50 232.3 GB 234.6 GB Won't fit 1.91
Q8_0 (GGUF) 8.50 232.3 GB 234.6 GB Won't fit 1.91
FP8 (E4M3) 8.00 218.9 GB 221.2 GB Won't fit 2.04
Q6_K 6.56 179.5 GB 181.8 GB Won't fit 2.49
Q5_K_M 5.67 155.2 GB 157.5 GB Won't fit 2.88
Q5_K_S 5.52 151.1 GB 153.4 GB Won't fit 2.96
Q4_K_M 4.85 132.8 GB 135.1 GB Won't fit 3.36
Q4_K_S 4.58 125.5 GB 127.8 GB Won't fit 3.54
Q4_0 4.55 124.7 GB 127.0 GB Won't fit 3.60
AWQ 4-bit 4.25 118.0 GB 120.3 GB Won't fit 3.79
GPTQ 4-bit 4.25 118.0 GB 120.3 GB Won't fit 3.79
MXFP4 4.25 118.0 GB 120.3 GB Won't fit 3.79
IQ4_XS 4.25 116.5 GB 118.8 GB Won't fit 3.83
Q3_K_M 3.91 107.2 GB 109.5 GB Won't fit 4.17
IQ3_M 3.70 101.5 GB 103.8 GB Won't fit 4.43
IQ3_XXS 3.06 84.1 GB 86.4 GB Won't fit 5.35
Q2_K 2.63 72.4 GB 74.7 GB Won't fit 6.23
IQ2_XXS 2.06 56.9 GB 59.2 GB Won't fit 7.97
IQ1_M 1.75 48.4 GB 50.7 GB Won't fit 9.51

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